D81 Combined immunodeficiencies
ICD-10-CM category D81 sits in Chapter 3 (Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism, D50-D89). It contains 17 billable codes for FY2027, effective October 1, 2026 to September 30, 2027. Always code to the most specific code available: a code with more characters that describes the diagnosis more precisely takes priority over a shorter one.
Subcategories
D81.3 Adenosine deaminase [ADA] deficiencyD81.8 Other combined immunodeficienciesD81.81 Biotin-dependent carboxylase deficiency
Billable codes in D81
| Code | Description |
|---|---|
D81.0 | Severe combined immunodeficiency [SCID] with reticular dysgenesis |
D81.1 | Severe combined immunodeficiency [SCID] with low T- and B-cell numbers |
D81.2 | Severe combined immunodeficiency [SCID] with low or normal B-cell numbers |
D81.30 | Adenosine deaminase deficiency, unspecified |
D81.31 | Severe combined immunodeficiency due to adenosine deaminase deficiency |
D81.32 | Adenosine deaminase 2 deficiency |
D81.39 | Other adenosine deaminase deficiency |
D81.4 | Nezelof's syndrome |
D81.5 | Purine nucleoside phosphorylase [PNP] deficiency |
D81.6 | Major histocompatibility complex class I deficiency |
D81.7 | Major histocompatibility complex class II deficiency |
D81.810 | Biotinidase deficiency |
D81.818 | Other biotin-dependent carboxylase deficiency |
D81.819 | Biotin-dependent carboxylase deficiency, unspecified |
D81.82 | Activated Phosphoinositide 3-kinase Delta Syndrome [APDS] |
D81.89 | Other combined immunodeficiencies |
D81.9 | Combined immunodeficiency, unspecified |
Search within ICD-10-CM for D81 and related codes
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